Who's disqualified from participating in clinical trials and why?
This is a good place to start. For who do psychedelics pose the biggest risk? To answer this question, let's look at what types of conditions disqualify people from participating in clinical trials with psilocybin. Currently, the main conditions include hypertension and other underlying heart conditions; history of psychosis or a psychotic spectrum disorder like schizophrenia; bipolar disorder; other persistent severe mental illness; as well as first-degree relative with any of these psychiatric conditions.
SSRI antidepressants: will lessen the effects of psilocybin, even if the journeyer skipped that day’s do
NO GO:
- History of violent or dissociative behavior, to a more serious personality disorder
- History of epilepsy, seizures and cardiovascular disease
- Concern around the comedown. Psilocybin can change the neural chemical balance of someone with epilepsy and can reset their seizure threshold. Be cautious with those who have had substance-induced seizure because there is a rick of substance induction, which is a type of substance-induced psychosis.
- Hypertension & open heart surgery
- Because psilocybin affects serotonin pathways it can transiently run the risk of elevating blood pressure and altering body temperature. It can modestly increase blood pressure by 20 points.
- Someone with open heart surgery could go into cardiac arrest and die.
- History of psychosis or a psychotic spectrum disorder, like schizophrenia, bipolar or other persistent severe mental illness, or first-degree relative with any of these psychiatric conditions
- Psychotic spectrum disorders: It’s generally believed that taking a psychedelic when you re generally predisposed to experience psychosis can speed along the time of your first psychotic break. It’s especially dangerous for young people with a predisposition to psychosis to take psilocybin.
- Bipolar disorder: Someone with bipolar disorder to a family hostly of bipolar disorder could be thrust into a manic episode following a psychedelic experience. Bipolar 1 is more at risk than bipolar 2, yet both should be excluded.
- Suicide attempts: Extra precaution with those with a history go serious suicide attempts, to ensure participants don’t hurt themselves.